Imodur
Brand names,
Imodur
Analogs
Imodur
Brand Names Mixture
Imodur
Chemical_Formula
C6H9NO6
Imodur
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Imodur
fda sheet
Imodur
msds (material safety sheet)
Imodur
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Imodur
Molecular Weight
191.139 g/mol
Imodur
Melting Point
88-91oC
Imodur
H2O Solubility
1.07E+005 mg/L
Imodur
State
Solid
Imodur
LogP
-0.15
Imodur
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Imodur
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Imodur
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Imodur
Absorption
100%
Imodur
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Imodur
Patient Information
Imodur
Organisms Affected
Humans and other mammals