Monolong
Brand names,
Monolong
Analogs
Monolong
Brand Names Mixture
Monolong
Chemical_Formula
C6H9NO6
Monolong
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monolong
fda sheet
Monolong
msds (material safety sheet)
Monolong
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monolong
Molecular Weight
191.139 g/mol
Monolong
Melting Point
88-91oC
Monolong
H2O Solubility
1.07E+005 mg/L
Monolong
State
Solid
Monolong
LogP
-0.15
Monolong
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monolong
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monolong
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monolong
Absorption
100%
Monolong
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monolong
Patient Information
Monolong
Organisms Affected
Humans and other mammals