Isomonat
Brand names,
Isomonat
Analogs
Isomonat
Brand Names Mixture
Isomonat
Chemical_Formula
C6H9NO6
Isomonat
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Isomonat
fda sheet
Isomonat
msds (material safety sheet)
Isomonat
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Isomonat
Molecular Weight
191.139 g/mol
Isomonat
Melting Point
88-91oC
Isomonat
H2O Solubility
1.07E+005 mg/L
Isomonat
State
Solid
Isomonat
LogP
-0.15
Isomonat
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Isomonat
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Isomonat
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Isomonat
Absorption
100%
Isomonat
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Isomonat
Patient Information
Isomonat
Organisms Affected
Humans and other mammals