Metronidazole
Brand names,
Metronidazole
Analogs
Metronidazole
Brand Names Mixture
Metronidazole
Chemical_Formula
C6H9N3O3
Metronidazole
RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
Metronidazole
fda sheet
Metronidazole
msds (material safety sheet)
Metronidazole
Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
Metronidazole
Molecular Weight
171.154 g/mol
Metronidazole
Melting Point
160 oC
Metronidazole
H2O Solubility
<0.1g/100mL
Metronidazole
State
Solid
Metronidazole
LogP
-0.262
Metronidazole
Dosage Forms
Tablet; Intravenous injection
Metronidazole
Indication
Treatment of acute acne rosacea
Metronidazole
Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Metronidazole
Absorption
Well absorbed
Metronidazole
side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Metronidazole
Patient Information
Metronidazole
Organisms Affected
Bacteria and protozoa