Trikojol
Brand names,
Trikojol
Analogs
Trikojol
Brand Names Mixture
Trikojol
Chemical_Formula
C6H9N3O3
Trikojol
RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
Trikojol
fda sheet
Trikojol
msds (material safety sheet)
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Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
Trikojol
Molecular Weight
171.154 g/mol
Trikojol
Melting Point
160 oC
Trikojol
H2O Solubility
<0.1g/100mL
Trikojol
State
Solid
Trikojol
LogP
-0.262
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Dosage Forms
Tablet; Intravenous injection
Trikojol
Indication
Treatment of acute acne rosacea
Trikojol
Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Trikojol
Absorption
Well absorbed
Trikojol
side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Trikojol
Patient Information
Trikojol
Organisms Affected
Bacteria and protozoa