Novonidazol
Brand names,
Novonidazol
Analogs
Novonidazol
Brand Names Mixture
Novonidazol
Chemical_Formula
C6H9N3O3
Novonidazol
RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
Novonidazol
fda sheet
Novonidazol
msds (material safety sheet)
Novonidazol
Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
Novonidazol
Molecular Weight
171.154 g/mol
Novonidazol
Melting Point
160 oC
Novonidazol
H2O Solubility
<0.1g/100mL
Novonidazol
State
Solid
Novonidazol
LogP
-0.262
Novonidazol
Dosage Forms
Tablet; Intravenous injection
Novonidazol
Indication
Treatment of acute acne rosacea
Novonidazol
Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Novonidazol
Absorption
Well absorbed
Novonidazol
side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Novonidazol
Patient Information
Novonidazol
Organisms Affected
Bacteria and protozoa