Methronidazole
Brand names,
Methronidazole
Analogs
Methronidazole
Brand Names Mixture
Methronidazole
Chemical_Formula
C6H9N3O3
Methronidazole
RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
Methronidazole
fda sheet
Methronidazole
msds (material safety sheet)
Methronidazole
Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
Methronidazole
Molecular Weight
171.154 g/mol
Methronidazole
Melting Point
160 oC
Methronidazole
H2O Solubility
<0.1g/100mL
Methronidazole
State
Solid
Methronidazole
LogP
-0.262
Methronidazole
Dosage Forms
Tablet; Intravenous injection
Methronidazole
Indication
Treatment of acute acne rosacea
Methronidazole
Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Methronidazole
Absorption
Well absorbed
Methronidazole
side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Methronidazole
Patient Information
Methronidazole
Organisms Affected
Bacteria and protozoa