Trikamon
Brand names,
Trikamon
Analogs
Trikamon
Brand Names Mixture
Trikamon
Chemical_Formula
C6H9N3O3
Trikamon
RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
Trikamon
fda sheet
Trikamon
msds (material safety sheet)
Trikamon
Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
Trikamon
Molecular Weight
171.154 g/mol
Trikamon
Melting Point
160 oC
Trikamon
H2O Solubility
<0.1g/100mL
Trikamon
State
Solid
Trikamon
LogP
-0.262
Trikamon
Dosage Forms
Tablet; Intravenous injection
Trikamon
Indication
Treatment of acute acne rosacea
Trikamon
Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Trikamon
Absorption
Well absorbed
Trikamon
side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Trikamon
Patient Information
Trikamon
Organisms Affected
Bacteria and protozoa