Monasin
Brand names,
Monasin
Analogs
Monasin
Brand Names Mixture
Monasin
Chemical_Formula
C6H9N3O3
Monasin
RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
Monasin
fda sheet
Monasin
msds (material safety sheet)
Monasin
Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
Monasin
Molecular Weight
171.154 g/mol
Monasin
Melting Point
160 oC
Monasin
H2O Solubility
<0.1g/100mL
Monasin
State
Solid
Monasin
LogP
-0.262
Monasin
Dosage Forms
Tablet; Intravenous injection
Monasin
Indication
Treatment of acute acne rosacea
Monasin
Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Monasin
Absorption
Well absorbed
Monasin
side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Monasin
Patient Information
Monasin
Organisms Affected
Bacteria and protozoa