Fossyol
Brand names,
Fossyol
Analogs
Fossyol
Brand Names Mixture
Fossyol
Chemical_Formula
C6H9N3O3
Fossyol
RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
Fossyol
fda sheet
Fossyol
msds (material safety sheet)
Fossyol
Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
Fossyol
Molecular Weight
171.154 g/mol
Fossyol
Melting Point
160 oC
Fossyol
H2O Solubility
<0.1g/100mL
Fossyol
State
Solid
Fossyol
LogP
-0.262
Fossyol
Dosage Forms
Tablet; Intravenous injection
Fossyol
Indication
Treatment of acute acne rosacea
Fossyol
Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Fossyol
Absorption
Well absorbed
Fossyol
side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Fossyol
Patient Information
Fossyol
Organisms Affected
Bacteria and protozoa