Monagyl
Brand names,
Monagyl
Analogs
Monagyl
Brand Names Mixture
Monagyl
Chemical_Formula
C6H9N3O3
Monagyl
RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
Monagyl
fda sheet
Monagyl
msds (material safety sheet)
Monagyl
Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
Monagyl
Molecular Weight
171.154 g/mol
Monagyl
Melting Point
160 oC
Monagyl
H2O Solubility
<0.1g/100mL
Monagyl
State
Solid
Monagyl
LogP
-0.262
Monagyl
Dosage Forms
Tablet; Intravenous injection
Monagyl
Indication
Treatment of acute acne rosacea
Monagyl
Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Monagyl
Absorption
Well absorbed
Monagyl
side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Monagyl
Patient Information
Monagyl
Organisms Affected
Bacteria and protozoa