Apo-Metronidazole
Brand names,
Apo-Metronidazole
Analogs
Apo-Metronidazole
Brand Names Mixture
Apo-Metronidazole
Chemical_Formula
C6H9N3O3
Apo-Metronidazole
RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
Apo-Metronidazole
fda sheet
Apo-Metronidazole
msds (material safety sheet)
Apo-Metronidazole
Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
Apo-Metronidazole
Molecular Weight
171.154 g/mol
Apo-Metronidazole
Melting Point
160 oC
Apo-Metronidazole
H2O Solubility
<0.1g/100mL
Apo-Metronidazole
State
Solid
Apo-Metronidazole
LogP
-0.262
Apo-Metronidazole
Dosage Forms
Tablet; Intravenous injection
Apo-Metronidazole
Indication
Treatment of acute acne rosacea
Apo-Metronidazole
Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Apo-Metronidazole
Absorption
Well absorbed
Apo-Metronidazole
side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Apo-Metronidazole
Patient Information
Apo-Metronidazole
Organisms Affected
Bacteria and protozoa