Trimeks
Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C6H9N3O3
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RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
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Molecular Weight
171.154 g/mol
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Melting Point
160 oC
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H2O Solubility
<0.1g/100mL
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State
Solid
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LogP
-0.262
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Dosage Forms
Tablet; Intravenous injection
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Indication
Treatment of acute acne rosacea
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Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
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Absorption
Well absorbed
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side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
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Patient Information
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Organisms Affected
Bacteria and protozoa