Metrotop
Brand names,
Metrotop
Analogs
Metrotop
Brand Names Mixture
Metrotop
Chemical_Formula
C6H9N3O3
Metrotop
RX_link
http://www.rxlist.com/cgi/generic2/metron.htm
Metrotop
fda sheet
Metrotop
msds (material safety sheet)
Metrotop
Synthesis Reference
Jacob et al., U.S. Pat. 2,944,061 (1960)
Metrotop
Molecular Weight
171.154 g/mol
Metrotop
Melting Point
160 oC
Metrotop
H2O Solubility
<0.1g/100mL
Metrotop
State
Solid
Metrotop
LogP
-0.262
Metrotop
Dosage Forms
Tablet; Intravenous injection
Metrotop
Indication
Treatment of acute acne rosacea
Metrotop
Pharmacology
Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.
Metrotop
Absorption
Well absorbed
Metrotop
side effects and Toxicity
Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, LD50=500 mg/kg/day (orally in rat)
Metrotop
Patient Information
Metrotop
Organisms Affected
Bacteria and protozoa