beta-Lindane
Brand names,
beta-Lindane
Analogs
beta-Lindane
Brand Names Mixture
beta-Lindane
Chemical_Formula
C24H31ClO7
beta-Lindane
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
beta-Lindane
fda sheet
beta-Lindane
msds (material safety sheet)
beta-Lindane
Synthesis Reference
No information avaliable
beta-Lindane
Molecular Weight
466.951 g/mol
beta-Lindane
Melting Point
220-224 oC
beta-Lindane
H2O Solubility
5 mg/mL
beta-Lindane
State
Solid
beta-Lindane
LogP
4.004
beta-Lindane
Dosage Forms
Solution; Spray
beta-Lindane
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
beta-Lindane
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
beta-Lindane
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
beta-Lindane
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
beta-Lindane
Patient Information
beta-Lindane
Organisms Affected
Humans and other mammals