Gammasan
Brand names,
Gammasan
Analogs
Gammasan
Brand Names Mixture
Gammasan
Chemical_Formula
C24H31ClO7
Gammasan
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Gammasan
fda sheet
Gammasan
msds (material safety sheet)
Gammasan
Synthesis Reference
No information avaliable
Gammasan
Molecular Weight
466.951 g/mol
Gammasan
Melting Point
220-224 oC
Gammasan
H2O Solubility
5 mg/mL
Gammasan
State
Solid
Gammasan
LogP
4.004
Gammasan
Dosage Forms
Solution; Spray
Gammasan
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Gammasan
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Gammasan
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Gammasan
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Gammasan
Patient Information
Gammasan
Organisms Affected
Humans and other mammals