Gammexane
Brand names,
Gammexane
Analogs
Gammexane
Brand Names Mixture
Gammexane
Chemical_Formula
C24H31ClO7
Gammexane
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Gammexane
fda sheet
Gammexane
msds (material safety sheet)
Gammexane
Synthesis Reference
No information avaliable
Gammexane
Molecular Weight
466.951 g/mol
Gammexane
Melting Point
220-224 oC
Gammexane
H2O Solubility
5 mg/mL
Gammexane
State
Solid
Gammexane
LogP
4.004
Gammexane
Dosage Forms
Solution; Spray
Gammexane
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Gammexane
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Gammexane
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Gammexane
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Gammexane
Patient Information
Gammexane
Organisms Affected
Humans and other mammals