Lindatox
Brand names,
Lindatox
Analogs
Lindatox
Brand Names Mixture
Lindatox
Chemical_Formula
C24H31ClO7
Lindatox
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Lindatox
fda sheet
Lindatox
msds (material safety sheet)
Lindatox
Synthesis Reference
No information avaliable
Lindatox
Molecular Weight
466.951 g/mol
Lindatox
Melting Point
220-224 oC
Lindatox
H2O Solubility
5 mg/mL
Lindatox
State
Solid
Lindatox
LogP
4.004
Lindatox
Dosage Forms
Solution; Spray
Lindatox
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Lindatox
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Lindatox
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Lindatox
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Lindatox
Patient Information
Lindatox
Organisms Affected
Humans and other mammals