Milbol 49
Brand names,
Milbol 49
Analogs
Milbol 49
Brand Names Mixture
Milbol 49
Chemical_Formula
C24H31ClO7
Milbol 49
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Milbol 49
fda sheet
Milbol 49
msds (material safety sheet)
Milbol 49
Synthesis Reference
No information avaliable
Milbol 49
Molecular Weight
466.951 g/mol
Milbol 49
Melting Point
220-224 oC
Milbol 49
H2O Solubility
5 mg/mL
Milbol 49
State
Solid
Milbol 49
LogP
4.004
Milbol 49
Dosage Forms
Solution; Spray
Milbol 49
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Milbol 49
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Milbol 49
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Milbol 49
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Milbol 49
Patient Information
Milbol 49
Organisms Affected
Humans and other mammals