Hexit
Brand names,
Hexit
Analogs
Hexit
Brand Names Mixture
Hexit
Chemical_Formula
C24H31ClO7
Hexit
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Hexit
fda sheet
Hexit
msds (material safety sheet)
Hexit
Synthesis Reference
No information avaliable
Hexit
Molecular Weight
466.951 g/mol
Hexit
Melting Point
220-224 oC
Hexit
H2O Solubility
5 mg/mL
Hexit
State
Solid
Hexit
LogP
4.004
Hexit
Dosage Forms
Solution; Spray
Hexit
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Hexit
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Hexit
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Hexit
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Hexit
Patient Information
Hexit
Organisms Affected
Humans and other mammals