Aplidal
Brand names,
Aplidal
Analogs
Aplidal
Brand Names Mixture
Aplidal
Chemical_Formula
C24H31ClO7
Aplidal
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Aplidal
fda sheet
Aplidal
msds (material safety sheet)
Aplidal
Synthesis Reference
No information avaliable
Aplidal
Molecular Weight
466.951 g/mol
Aplidal
Melting Point
220-224 oC
Aplidal
H2O Solubility
5 mg/mL
Aplidal
State
Solid
Aplidal
LogP
4.004
Aplidal
Dosage Forms
Solution; Spray
Aplidal
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Aplidal
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Aplidal
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Aplidal
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Aplidal
Patient Information
Aplidal
Organisms Affected
Humans and other mammals