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Aplidal Brand names, Aplidal Analogs

Aplidal Brand Names Mixture

  • No information avaliable

Aplidal Chemical_Formula

C24H31ClO7

Aplidal RX_link

http://www.rxlist.com/cgi/generic2/lotemax.htm

Aplidal fda sheet

Aplidal FDA

Aplidal msds (material safety sheet)

Aplidal MSDS

Aplidal Synthesis Reference

No information avaliable

Aplidal Molecular Weight

466.951 g/mol

Aplidal Melting Point

220-224 oC

Aplidal H2O Solubility

5 mg/mL

Aplidal State

Solid

Aplidal LogP

4.004

Aplidal Dosage Forms

Solution; Spray

Aplidal Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

Aplidal Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

Aplidal Absorption

Very limited systemic absorption, but good absorption at the point of delivery.

Aplidal side effects and Toxicity

Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.

Aplidal Patient Information

Aplidal Organisms Affected

Humans and other mammals