beta-BHC
Brand names,
beta-BHC
Analogs
beta-BHC
Brand Names Mixture
beta-BHC
Chemical_Formula
C24H31ClO7
beta-BHC
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
beta-BHC
fda sheet
beta-BHC
msds (material safety sheet)
beta-BHC
Synthesis Reference
No information avaliable
beta-BHC
Molecular Weight
466.951 g/mol
beta-BHC
Melting Point
220-224 oC
beta-BHC
H2O Solubility
5 mg/mL
beta-BHC
State
Solid
beta-BHC
LogP
4.004
beta-BHC
Dosage Forms
Solution; Spray
beta-BHC
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
beta-BHC
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
beta-BHC
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
beta-BHC
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
beta-BHC
Patient Information
beta-BHC
Organisms Affected
Humans and other mammals