Aparasin
Brand names,
Aparasin
Analogs
Aparasin
Brand Names Mixture
Aparasin
Chemical_Formula
C24H31ClO7
Aparasin
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Aparasin
fda sheet
Aparasin
msds (material safety sheet)
Aparasin
Synthesis Reference
No information avaliable
Aparasin
Molecular Weight
466.951 g/mol
Aparasin
Melting Point
220-224 oC
Aparasin
H2O Solubility
5 mg/mL
Aparasin
State
Solid
Aparasin
LogP
4.004
Aparasin
Dosage Forms
Solution; Spray
Aparasin
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Aparasin
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Aparasin
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Aparasin
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Aparasin
Patient Information
Aparasin
Organisms Affected
Humans and other mammals