Agrocide WP
Brand names,
Agrocide WP
Analogs
Agrocide WP
Brand Names Mixture
Agrocide WP
Chemical_Formula
C24H31ClO7
Agrocide WP
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Agrocide WP
fda sheet
Agrocide WP
msds (material safety sheet)
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Synthesis Reference
No information avaliable
Agrocide WP
Molecular Weight
466.951 g/mol
Agrocide WP
Melting Point
220-224 oC
Agrocide WP
H2O Solubility
5 mg/mL
Agrocide WP
State
Solid
Agrocide WP
LogP
4.004
Agrocide WP
Dosage Forms
Solution; Spray
Agrocide WP
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Agrocide WP
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Agrocide WP
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Agrocide WP
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Agrocide WP
Patient Information
Agrocide WP
Organisms Affected
Humans and other mammals