Chloresene
Brand names,
Chloresene
Analogs
Chloresene
Brand Names Mixture
Chloresene
Chemical_Formula
C24H31ClO7
Chloresene
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Chloresene
fda sheet
Chloresene
msds (material safety sheet)
Chloresene
Synthesis Reference
No information avaliable
Chloresene
Molecular Weight
466.951 g/mol
Chloresene
Melting Point
220-224 oC
Chloresene
H2O Solubility
5 mg/mL
Chloresene
State
Solid
Chloresene
LogP
4.004
Chloresene
Dosage Forms
Solution; Spray
Chloresene
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Chloresene
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Chloresene
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Chloresene
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Chloresene
Patient Information
Chloresene
Organisms Affected
Humans and other mammals