Bexol
Brand names,
Bexol
Analogs
Bexol
Brand Names Mixture
Bexol
Chemical_Formula
C24H31ClO7
Bexol
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Bexol
fda sheet
Bexol
msds (material safety sheet)
Bexol
Synthesis Reference
No information avaliable
Bexol
Molecular Weight
466.951 g/mol
Bexol
Melting Point
220-224 oC
Bexol
H2O Solubility
5 mg/mL
Bexol
State
Solid
Bexol
LogP
4.004
Bexol
Dosage Forms
Solution; Spray
Bexol
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Bexol
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Bexol
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Bexol
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Bexol
Patient Information
Bexol
Organisms Affected
Humans and other mammals