HCCH
Brand names,
HCCH
Analogs
HCCH
Brand Names Mixture
HCCH
Chemical_Formula
C24H31ClO7
HCCH
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
HCCH
fda sheet
HCCH
msds (material safety sheet)
HCCH
Synthesis Reference
No information avaliable
HCCH
Molecular Weight
466.951 g/mol
HCCH
Melting Point
220-224 oC
HCCH
H2O Solubility
5 mg/mL
HCCH
State
Solid
HCCH
LogP
4.004
HCCH
Dosage Forms
Solution; Spray
HCCH
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
HCCH
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
HCCH
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
HCCH
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
HCCH
Patient Information
HCCH
Organisms Affected
Humans and other mammals