HCCH en es it fr

HCCH Brand names, HCCH Analogs

HCCH Brand Names Mixture

  • No information avaliable

HCCH Chemical_Formula

C24H31ClO7

HCCH RX_link

http://www.rxlist.com/cgi/generic2/lotemax.htm

HCCH fda sheet

HCCH FDA

HCCH msds (material safety sheet)

HCCH MSDS

HCCH Synthesis Reference

No information avaliable

HCCH Molecular Weight

466.951 g/mol

HCCH Melting Point

220-224 oC

HCCH H2O Solubility

5 mg/mL

HCCH State

Solid

HCCH LogP

4.004

HCCH Dosage Forms

Solution; Spray

HCCH Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

HCCH Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

HCCH Absorption

Very limited systemic absorption, but good absorption at the point of delivery.

HCCH side effects and Toxicity

Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.

HCCH Patient Information

HCCH Organisms Affected

Humans and other mammals