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HGI Brand names, HGI Analogs

HGI Brand Names Mixture

  • No information avaliable

HGI Chemical_Formula

C24H31ClO7

HGI RX_link

http://www.rxlist.com/cgi/generic2/lotemax.htm

HGI fda sheet

HGI FDA

HGI msds (material safety sheet)

HGI MSDS

HGI Synthesis Reference

No information avaliable

HGI Molecular Weight

466.951 g/mol

HGI Melting Point

220-224 oC

HGI H2O Solubility

5 mg/mL

HGI State

Solid

HGI LogP

4.004

HGI Dosage Forms

Solution; Spray

HGI Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

HGI Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

HGI Absorption

Very limited systemic absorption, but good absorption at the point of delivery.

HGI side effects and Toxicity

Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.

HGI Patient Information

HGI Organisms Affected

Humans and other mammals