Ben-Hex
Brand names,
Ben-Hex
Analogs
Ben-Hex
Brand Names Mixture
Ben-Hex
Chemical_Formula
C24H31ClO7
Ben-Hex
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Ben-Hex
fda sheet
Ben-Hex
msds (material safety sheet)
Ben-Hex
Synthesis Reference
No information avaliable
Ben-Hex
Molecular Weight
466.951 g/mol
Ben-Hex
Melting Point
220-224 oC
Ben-Hex
H2O Solubility
5 mg/mL
Ben-Hex
State
Solid
Ben-Hex
LogP
4.004
Ben-Hex
Dosage Forms
Solution; Spray
Ben-Hex
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Ben-Hex
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Ben-Hex
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Ben-Hex
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Ben-Hex
Patient Information
Ben-Hex
Organisms Affected
Humans and other mammals