Celanex
Brand names,
Celanex
Analogs
Celanex
Brand Names Mixture
Celanex
Chemical_Formula
C24H31ClO7
Celanex
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Celanex
fda sheet
Celanex
msds (material safety sheet)
Celanex
Synthesis Reference
No information avaliable
Celanex
Molecular Weight
466.951 g/mol
Celanex
Melting Point
220-224 oC
Celanex
H2O Solubility
5 mg/mL
Celanex
State
Solid
Celanex
LogP
4.004
Celanex
Dosage Forms
Solution; Spray
Celanex
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Celanex
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Celanex
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Celanex
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Celanex
Patient Information
Celanex
Organisms Affected
Humans and other mammals