Aalindan
Brand names,
Aalindan
Analogs
Aalindan
Brand Names Mixture
Aalindan
Chemical_Formula
C24H31ClO7
Aalindan
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Aalindan
fda sheet
Aalindan
msds (material safety sheet)
Aalindan
Synthesis Reference
No information avaliable
Aalindan
Molecular Weight
466.951 g/mol
Aalindan
Melting Point
220-224 oC
Aalindan
H2O Solubility
5 mg/mL
Aalindan
State
Solid
Aalindan
LogP
4.004
Aalindan
Dosage Forms
Solution; Spray
Aalindan
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Aalindan
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Aalindan
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Aalindan
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Aalindan
Patient Information
Aalindan
Organisms Affected
Humans and other mammals