Codechine
Brand names,
Codechine
Analogs
Codechine
Brand Names Mixture
Codechine
Chemical_Formula
C24H31ClO7
Codechine
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Codechine
fda sheet
Codechine
msds (material safety sheet)
Codechine
Synthesis Reference
No information avaliable
Codechine
Molecular Weight
466.951 g/mol
Codechine
Melting Point
220-224 oC
Codechine
H2O Solubility
5 mg/mL
Codechine
State
Solid
Codechine
LogP
4.004
Codechine
Dosage Forms
Solution; Spray
Codechine
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Codechine
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Codechine
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Codechine
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Codechine
Patient Information
Codechine
Organisms Affected
Humans and other mammals