Dol Granule
Brand names,
Dol Granule
Analogs
Dol Granule
Brand Names Mixture
Dol Granule
Chemical_Formula
C24H31ClO7
Dol Granule
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Dol Granule
fda sheet
Dol Granule
msds (material safety sheet)
Dol Granule
Synthesis Reference
No information avaliable
Dol Granule
Molecular Weight
466.951 g/mol
Dol Granule
Melting Point
220-224 oC
Dol Granule
H2O Solubility
5 mg/mL
Dol Granule
State
Solid
Dol Granule
LogP
4.004
Dol Granule
Dosage Forms
Solution; Spray
Dol Granule
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Dol Granule
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Dol Granule
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Dol Granule
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Dol Granule
Patient Information
Dol Granule
Organisms Affected
Humans and other mammals