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Nicochloran Brand names, Nicochloran Analogs

Nicochloran Brand Names Mixture

  • No information avaliable

Nicochloran Chemical_Formula

C24H31ClO7

Nicochloran RX_link

http://www.rxlist.com/cgi/generic2/lotemax.htm

Nicochloran fda sheet

Nicochloran FDA

Nicochloran msds (material safety sheet)

Nicochloran MSDS

Nicochloran Synthesis Reference

No information avaliable

Nicochloran Molecular Weight

466.951 g/mol

Nicochloran Melting Point

220-224 oC

Nicochloran H2O Solubility

5 mg/mL

Nicochloran State

Solid

Nicochloran LogP

4.004

Nicochloran Dosage Forms

Solution; Spray

Nicochloran Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

Nicochloran Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

Nicochloran Absorption

Very limited systemic absorption, but good absorption at the point of delivery.

Nicochloran side effects and Toxicity

Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.

Nicochloran Patient Information

Nicochloran Organisms Affected

Humans and other mammals