Lidenal
Brand names,
Lidenal
Analogs
Lidenal
Brand Names Mixture
Lidenal
Chemical_Formula
C24H31ClO7
Lidenal
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Lidenal
fda sheet
Lidenal
msds (material safety sheet)
Lidenal
Synthesis Reference
No information avaliable
Lidenal
Molecular Weight
466.951 g/mol
Lidenal
Melting Point
220-224 oC
Lidenal
H2O Solubility
5 mg/mL
Lidenal
State
Solid
Lidenal
LogP
4.004
Lidenal
Dosage Forms
Solution; Spray
Lidenal
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Lidenal
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Lidenal
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Lidenal
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Lidenal
Patient Information
Lidenal
Organisms Affected
Humans and other mammals