Lorexane
Brand names,
Lorexane
Analogs
Lorexane
Brand Names Mixture
Lorexane
Chemical_Formula
C24H31ClO7
Lorexane
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Lorexane
fda sheet
Lorexane
msds (material safety sheet)
Lorexane
Synthesis Reference
No information avaliable
Lorexane
Molecular Weight
466.951 g/mol
Lorexane
Melting Point
220-224 oC
Lorexane
H2O Solubility
5 mg/mL
Lorexane
State
Solid
Lorexane
LogP
4.004
Lorexane
Dosage Forms
Solution; Spray
Lorexane
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Lorexane
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Lorexane
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Lorexane
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Lorexane
Patient Information
Lorexane
Organisms Affected
Humans and other mammals