Gamene
Brand names,
Gamene
Analogs
Gamene
Brand Names Mixture
Gamene
Chemical_Formula
C24H31ClO7
Gamene
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Gamene
fda sheet
Gamene
msds (material safety sheet)
Gamene
Synthesis Reference
No information avaliable
Gamene
Molecular Weight
466.951 g/mol
Gamene
Melting Point
220-224 oC
Gamene
H2O Solubility
5 mg/mL
Gamene
State
Solid
Gamene
LogP
4.004
Gamene
Dosage Forms
Solution; Spray
Gamene
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Gamene
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Gamene
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Gamene
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Gamene
Patient Information
Gamene
Organisms Affected
Humans and other mammals