PharmacyCodes



DBH en es it fr

DBH Brand names, DBH Analogs

DBH Brand Names Mixture

  • No information avaliable

DBH Chemical_Formula

C24H31ClO7

DBH RX_link

http://www.rxlist.com/cgi/generic2/lotemax.htm

DBH fda sheet

DBH FDA

DBH msds (material safety sheet)

DBH MSDS

DBH Synthesis Reference

No information avaliable

DBH Molecular Weight

466.951 g/mol

DBH Melting Point

220-224 oC

DBH H2O Solubility

5 mg/mL

DBH State

Solid

DBH LogP

4.004

DBH Dosage Forms

Solution; Spray

DBH Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

DBH Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

DBH Absorption

Very limited systemic absorption, but good absorption at the point of delivery.

DBH side effects and Toxicity

Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.

DBH Patient Information

DBH Organisms Affected

Humans and other mammals