Lendine
Brand names,
Lendine
Analogs
Lendine
Brand Names Mixture
Lendine
Chemical_Formula
C24H31ClO7
Lendine
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Lendine
fda sheet
Lendine
msds (material safety sheet)
Lendine
Synthesis Reference
No information avaliable
Lendine
Molecular Weight
466.951 g/mol
Lendine
Melting Point
220-224 oC
Lendine
H2O Solubility
5 mg/mL
Lendine
State
Solid
Lendine
LogP
4.004
Lendine
Dosage Forms
Solution; Spray
Lendine
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Lendine
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Lendine
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Lendine
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Lendine
Patient Information
Lendine
Organisms Affected
Humans and other mammals