Scabene
Brand names,
Scabene
Analogs
Scabene
Brand Names Mixture
Scabene
Chemical_Formula
C24H31ClO7
Scabene
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Scabene
fda sheet
Scabene
msds (material safety sheet)
Scabene
Synthesis Reference
No information avaliable
Scabene
Molecular Weight
466.951 g/mol
Scabene
Melting Point
220-224 oC
Scabene
H2O Solubility
5 mg/mL
Scabene
State
Solid
Scabene
LogP
4.004
Scabene
Dosage Forms
Solution; Spray
Scabene
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Scabene
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Scabene
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Scabene
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Scabene
Patient Information
Scabene
Organisms Affected
Humans and other mammals