Esoderm
Brand names,
Esoderm
Analogs
Esoderm
Brand Names Mixture
Esoderm
Chemical_Formula
C24H31ClO7
Esoderm
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Esoderm
fda sheet
Esoderm
msds (material safety sheet)
Esoderm
Synthesis Reference
No information avaliable
Esoderm
Molecular Weight
466.951 g/mol
Esoderm
Melting Point
220-224 oC
Esoderm
H2O Solubility
5 mg/mL
Esoderm
State
Solid
Esoderm
LogP
4.004
Esoderm
Dosage Forms
Solution; Spray
Esoderm
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Esoderm
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Esoderm
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Esoderm
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Esoderm
Patient Information
Esoderm
Organisms Affected
Humans and other mammals