Lindosep
Brand names,
Lindosep
Analogs
Lindosep
Brand Names Mixture
Lindosep
Chemical_Formula
C24H31ClO7
Lindosep
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Lindosep
fda sheet
Lindosep
msds (material safety sheet)
Lindosep
Synthesis Reference
No information avaliable
Lindosep
Molecular Weight
466.951 g/mol
Lindosep
Melting Point
220-224 oC
Lindosep
H2O Solubility
5 mg/mL
Lindosep
State
Solid
Lindosep
LogP
4.004
Lindosep
Dosage Forms
Solution; Spray
Lindosep
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Lindosep
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Lindosep
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Lindosep
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Lindosep
Patient Information
Lindosep
Organisms Affected
Humans and other mammals