Linvur
Brand names,
Linvur
Analogs
Linvur
Brand Names Mixture
Linvur
Chemical_Formula
C24H31ClO7
Linvur
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Linvur
fda sheet
Linvur
msds (material safety sheet)
Linvur
Synthesis Reference
No information avaliable
Linvur
Molecular Weight
466.951 g/mol
Linvur
Melting Point
220-224 oC
Linvur
H2O Solubility
5 mg/mL
Linvur
State
Solid
Linvur
LogP
4.004
Linvur
Dosage Forms
Solution; Spray
Linvur
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Linvur
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Linvur
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Linvur
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Linvur
Patient Information
Linvur
Organisms Affected
Humans and other mammals