Hexachloran
Brand names,
Hexachloran
Analogs
Hexachloran
Brand Names Mixture
Hexachloran
Chemical_Formula
C24H31ClO7
Hexachloran
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Hexachloran
fda sheet
Hexachloran
msds (material safety sheet)
Hexachloran
Synthesis Reference
No information avaliable
Hexachloran
Molecular Weight
466.951 g/mol
Hexachloran
Melting Point
220-224 oC
Hexachloran
H2O Solubility
5 mg/mL
Hexachloran
State
Solid
Hexachloran
LogP
4.004
Hexachloran
Dosage Forms
Solution; Spray
Hexachloran
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Hexachloran
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Hexachloran
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Hexachloran
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Hexachloran
Patient Information
Hexachloran
Organisms Affected
Humans and other mammals