Lentox
Brand names,
Lentox
Analogs
Lentox
Brand Names Mixture
Lentox
Chemical_Formula
C24H31ClO7
Lentox
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Lentox
fda sheet
Lentox
msds (material safety sheet)
Lentox
Synthesis Reference
No information avaliable
Lentox
Molecular Weight
466.951 g/mol
Lentox
Melting Point
220-224 oC
Lentox
H2O Solubility
5 mg/mL
Lentox
State
Solid
Lentox
LogP
4.004
Lentox
Dosage Forms
Solution; Spray
Lentox
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Lentox
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Lentox
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Lentox
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Lentox
Patient Information
Lentox
Organisms Affected
Humans and other mammals