Heclotox
Brand names,
Heclotox
Analogs
Heclotox
Brand Names Mixture
Heclotox
Chemical_Formula
C24H31ClO7
Heclotox
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Heclotox
fda sheet
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msds (material safety sheet)
Heclotox
Synthesis Reference
No information avaliable
Heclotox
Molecular Weight
466.951 g/mol
Heclotox
Melting Point
220-224 oC
Heclotox
H2O Solubility
5 mg/mL
Heclotox
State
Solid
Heclotox
LogP
4.004
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Dosage Forms
Solution; Spray
Heclotox
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Heclotox
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Heclotox
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Heclotox
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
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Patient Information
Heclotox
Organisms Affected
Humans and other mammals