Indane
Brand names,
Indane
Analogs
Indane
Brand Names Mixture
Indane
Chemical_Formula
C24H31ClO7
Indane
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Indane
fda sheet
Indane
msds (material safety sheet)
Indane
Synthesis Reference
No information avaliable
Indane
Molecular Weight
466.951 g/mol
Indane
Melting Point
220-224 oC
Indane
H2O Solubility
5 mg/mL
Indane
State
Solid
Indane
LogP
4.004
Indane
Dosage Forms
Solution; Spray
Indane
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Indane
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Indane
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Indane
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Indane
Patient Information
Indane
Organisms Affected
Humans and other mammals