Hexachlorocyclohexane
Brand names,
Hexachlorocyclohexane
Analogs
Hexachlorocyclohexane
Brand Names Mixture
Hexachlorocyclohexane
Chemical_Formula
C24H31ClO7
Hexachlorocyclohexane
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Hexachlorocyclohexane
fda sheet
Hexachlorocyclohexane
msds (material safety sheet)
Hexachlorocyclohexane
Synthesis Reference
No information avaliable
Hexachlorocyclohexane
Molecular Weight
466.951 g/mol
Hexachlorocyclohexane
Melting Point
220-224 oC
Hexachlorocyclohexane
H2O Solubility
5 mg/mL
Hexachlorocyclohexane
State
Solid
Hexachlorocyclohexane
LogP
4.004
Hexachlorocyclohexane
Dosage Forms
Solution; Spray
Hexachlorocyclohexane
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Hexachlorocyclohexane
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Hexachlorocyclohexane
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Hexachlorocyclohexane
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Hexachlorocyclohexane
Patient Information
Hexachlorocyclohexane
Organisms Affected
Humans and other mammals