Agrocide III
Brand names,
Agrocide III
Analogs
Agrocide III
Brand Names Mixture
Agrocide III
Chemical_Formula
C24H31ClO7
Agrocide III
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Agrocide III
fda sheet
Agrocide III
msds (material safety sheet)
Agrocide III
Synthesis Reference
No information avaliable
Agrocide III
Molecular Weight
466.951 g/mol
Agrocide III
Melting Point
220-224 oC
Agrocide III
H2O Solubility
5 mg/mL
Agrocide III
State
Solid
Agrocide III
LogP
4.004
Agrocide III
Dosage Forms
Solution; Spray
Agrocide III
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Agrocide III
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Agrocide III
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Agrocide III
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Agrocide III
Patient Information
Agrocide III
Organisms Affected
Humans and other mammals