Hexachlorane
Brand names,
Hexachlorane
Analogs
Hexachlorane
Brand Names Mixture
Hexachlorane
Chemical_Formula
C24H31ClO7
Hexachlorane
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Hexachlorane
fda sheet
Hexachlorane
msds (material safety sheet)
Hexachlorane
Synthesis Reference
No information avaliable
Hexachlorane
Molecular Weight
466.951 g/mol
Hexachlorane
Melting Point
220-224 oC
Hexachlorane
H2O Solubility
5 mg/mL
Hexachlorane
State
Solid
Hexachlorane
LogP
4.004
Hexachlorane
Dosage Forms
Solution; Spray
Hexachlorane
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Hexachlorane
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Hexachlorane
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Hexachlorane
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Hexachlorane
Patient Information
Hexachlorane
Organisms Affected
Humans and other mammals